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In The News

• This Hydrogel Could Solve The Water-less Desert Crisis

• South Korean Scientists Work To Protect The Womb Lining To Increase Birth Rates

• Loading Cancer Killing Cells Into A 3D Printed Hydrogel Carrier

Research Updates

Injectable multifunctional carboxymethyl chitosan/hyaluronic acid hydrogel for drug delivery systems

• An injectable hydrogel that can be used as a drug delivery system was developed.

• It can be synthesized using a one-step approach and contains adipic acid dihydrazide (ADH) and calcium ions (Ca2+).

• The introduction of dynamic Schiff bases and coordination bonds provided injectable hydrogels with excellent mechanical properties, good self-healing properties, and pH responsiveness.

• Suitable timescale for application, the gelation time of the hydrogels under physiological conditions was approximately 54 s after injection.

• Through Korsmeyer-Peppas model kinetic analysis, the release mechanism of the hydrogels showed Fickian diffusion behaviour.

• These results showed that the developed injectable multifunctional hydrogel had good clinical application prospects in drug delivery systems.

Ultrafast and facile construction of programmable, multidimensional wrinkled-patterned polyacrylamide/sodium alginate hydrogels for human skin-like tactile perception

• A hydrogel that is programmable, multidimensional wrinkled-patterned hydrogels for human skin-like tactile perception has been developed.

• Made of polyacrylamide and sodium alginate, its forms a hard shell layer due to the coordination of carboxyl groups with Fe3+ during the stretch-recovery process. This results in a wrinkled surface with a high sensitivity pressure sensor that can be used for contact dynamic tactile perception and monitoring of various movement behaviors of the human body.

• The ability to simultaneously construct complex topologies from 1D to 3D with well-organized microstructure and controllable dimensions.

• The maintenance of a high sensitivity of up to 67.47 kPa−1 in 1000 compression cycles due to the unique surface and dual crosslinking network of the self-wrinkled hydrogel.

• The ultrafast release of pre-stretched PAM/SA gels in Fe3+ solutions induced the surface mechanical instability of gels, enabling the simultaneous construction of columns, lattices, cylinders and pyramids structure from 1D to 3D with well-organized wrinkled surface.

• This work develops a general strategy for constructing gels with controlled wavelengths and tailored multidimensional geometries by using ultrafast ion-induced gradients.

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